• Pleasing Outside Of Hotel

    Pleasing Outside Of Hotel

  • Well-Arranged Hotel Front Desk

    Well-Arranged Hotel Front Desk

  • Lobby with fireplace

    Lobby with fireplace

  • Comfortable Breakfast Room

    Comfortable Breakfast Room

  • Attractive Room With King Bed

    Attractive Room With King Bed

  • Guest room with queen beds

    Guest room with queen beds

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Select check-out date close

Welcome To Comfort Inn & Suites Santee, SC

Comfort Inn & Suites Santee SC is a cozy, comfortable and affordable place where you’ll be welcomed heartily. Stay with us at this well-regarded hotel in Santee SC and experience the best for less while taking in the abundant natural of beauty of Orangeburg County.

Our hotel is close to Lake Marion, a jewel of central South Carolina. We’re also the first and best place to choose when seeking a place to stay near Lake Marion Golf Course and Lake Marion Bass Fishing as well as Santee Wildlife Refuge, Palmetto Trail and the Santee Welcome Center.

Choose us over other hotels in Santee SC and you’ll get plenty of amenities. These include a satisfying free breakfast, free wifi, access to our fitness center and seasonal outdoor pool and more. We also have a business center for added convenience. Every guest room includes a fridge and microwave as well as premium bedding, a flat-screen television and a coffee maker. Some rooms have sofa beds too.

Plus, staying with us allows you to earn rewards like free nights with Choice Privileges Rewards, an industry leading loyalty program. So what’s not to like? Reserve a room with us right away and see for yourself how great your stay in Santee can be.

What can you see and do in Santee? Consider these attractions:

Santee State Park offers unmatched lakeside recreation – and it’s so close to our great hotel.

Santee National Wildlife Refuge is acres and miles of unspoiled wilderness for you to enjoy – and we’d enjoy hosting you in this area.

Don’t forget to shop and dine in Santee for a great local experience you can’t have anywhere else in the world.

Whatever you do, get outside. Year round, this city and area is geared toward great outdoor recreation.


Our Facilities

Free Hot Breakfast

Delicious Breakfast

Agileits W3layouts

Flat-screen TV

With Cable Channels

in Every Room

Agileits W3layouts

Free WiFi

Free Wireless High-Speed

Internet Access

In all areas

Agileits W3layouts

No Pets Allowed

Pets are not allowed

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Choice Privileges